Oxidative stress mediates the apoptosis and epigenetic modification of the Bcl-2 promoter via DNMT1 in a cigarette smoke-induced emphysema model

Abstract Background Emphysema is a crucial pathological characteristic of chronic obstructive pulmonary disease (COPD). Oxidative stress, apoptosis and epigenetic mechanisms contribute to the pathogenesis of emphysema. However, an attempt to accurately identify whether these mechanisms interact with...

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主要な著者:	Huihui Zeng, Tiao Li, Xue He, Shan Cai, Hong Luo, Ping Chen, Yan Chen
フォーマット:	Artigo
言語:	Inglês
出版事項:	BMC 2020-09-01
シリーズ:	Respiratory Research
主題:	Oxidative stress Apoptosis Hypermethylation Bcl-2 DNMT1
オンライン･アクセス:	http://link.springer.com/article/10.1186/s12931-020-01495-w
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