Structure of DNMT3B homo-oligomer reveals vulnerability to impairment by ICF mutations

In mammals, de novo DNA methyltransferase DNMT3B is essential for establishing DNA methylation patterns during embryonic development. Here the authors provide a structure-function characterization of homo-oligomeric DNMT3B, revealing the molecular basis for its vulnerability to ICF mutations.

Библиографические подробности

Главные авторы:	Linfeng Gao, Yiran Guo, Mahamaya Biswal, Jiuwei Lu, Jiekai Yin, Jian Fang, Xinyi Chen, Zengyu Shao, Mengjiang Huang, Yinsheng Wang, Gang Greg Wang, Jikui Song
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Nature Portfolio 2022-07-01
Серии:	Nature Communications
Online-ссылка:	https://doi.org/10.1038/s41467-022-31933-w
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