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Noncanonical WNT Activation in Human Right Ventricular Heart Failure

Background: No medical therapies exist to treat right ventricular (RV) remodeling and RV failure (RVF), in large part because molecular pathways that are specifically activated in pathologic human RV remodeling remain poorly defined. Murine models have suggested involvement of Wnt signaling, but thi...

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Principais autores: Jonathan J. Edwards, Jeffrey Brandimarto, Dong-Qing Hu, Sunhye Jeong, Nora Yucel, Li Li, Kenneth C. Bedi, Shogo Wada, Danielle Murashige, Hyun Tae V. Hwang, Mingming Zhao, Kenneth B. Margulies, Daniel Bernstein, Sushma Reddy, Zoltan Arany
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-10-01
coleção:Frontiers in Cardiovascular Medicine
Assuntos:
right ventricle (RV)
right ventricular (RV) failure
heart failure
Wnt
calpain
Ror2
Acesso em linha:https://www.frontiersin.org/article/10.3389/fcvm.2020.582407/full
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