Reduced synaptic vesicle protein 2A in extracellular vesicles and brains of Alzheimer’s disease: associations with Aβ, tau, synaptic proteins and APOE ε4

Abstract Background Alzheimer’s disease (AD) is characterized by accumulation of amyloid-β (Aβ) plaques, tau neurofibrillary Tangles and synaptic dysfunction. The aim of this study was to map the distributions of synaptic vesicle protein 2A (SV2A) and other synaptic proteins in the brain and the bra...

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Váldodahkkit:	Jana Nussbaumer, Aatmika Barve, Valentin Zufferey, Jeanne Espourteille, Tunahan Kirabali, Uwe Konietzko, Daniel Razansky, Axel Rominger, Agneta Nordberg, Luc Buée, Morvane Colin, Roger M. Nitsch, Christoph Hock, Kevin Richetin, Ruiqing Ni
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	BMC 2025-09-01
Ráidu:	Translational Neurodegeneration
Fáttát:	Amyloid-β Alzheimer’s disease APOE ε4 Extracellular vesicles Proteomics Synaptic vesicle protein 2A
Liŋkkat:	https://doi.org/10.1186/s40035-025-00508-2
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