Comprehensive interrogation of the ADAR2 deaminase domain for engineering enhanced RNA editing activity and specificity
Adenosine deaminases acting on RNA (ADARs) can be repurposed to enable programmable RNA editing, however their exogenous delivery leads to transcriptome-wide off-targeting, and additionally, enzymatic activity on certain RNA motifs, especially those flanked by a 5’ guanosine is very low thus limitin...
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| Asıl Yazarlar: | , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
eLife Sciences Publications Ltd
2022-01-01
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| Seri Bilgileri: | eLife |
| Konular: | |
| Online Erişim: | https://elifesciences.org/articles/75555 |
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