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A Cost-Effective and Easy to Assemble 3D Human Microchannel Blood–Brain Barrier Model and Its Application in Tumor Cell Adhesion Under Flow

By utilizing polydimethylsiloxane (PDMS), collagen hydrogel, and a cell line for human cerebral microvascular endothelial cells, we produced a 3D microchannel blood–brain barrier (BBB) model under physiological flow. This 3D BBB has a circular-shaped cross-section and a diameter of ~100 μm, which ca...

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Principais autores: Yunfei Li, Bingmei M. Fu
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2025-03-01
coleção:Cells
Assuntos:
engineered microvessel
microfluidic device
solute permeability
sodium fluorescein
dextran-70k
glycocalyx
Acesso em linha:https://www.mdpi.com/2073-4409/14/6/456
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