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Programmed PTH pulsatility coupled with piezoelectric stimulation via ultrasound-activated scaffolds synergizes deep bone defect regeneration

Large bone defects in deep anatomical regions continue to pose significant clinical challenges for osteogenic reconstruction. While pulsatile low-dose parathyroid hormone (PTH) administration shows therapeutic potential for bone regeneration, its effective delivery to deep tissue defects remains pro...

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Principais autores: Xin Wang, Linyuan Shu, Bohao Yin, Jianing Ding, Chenjun Liu, Xin Qi, Junjie Guan, Yuwei Ge, Xiaofeng Lian, Hui Sun, Wei Zhang
Format: Artigo
Sprog:Inglês
Udgivet: KeAi Communications Co., Ltd. 2026-03-01
Serier:Bioactive Materials
Fag:
Bone regeneration
Pulsatile PTH release
Piezoelectric scaffold
Ultrasound stimulation
Osteogenic differentiation
Online adgang:http://www.sciencedirect.com/science/article/pii/S2452199X2500502X
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