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Targeted Quantification of Carbon Metabolites Identifies Metabolic Progression Markers and an Undiagnosed Case of SDH-Deficient Clear Cell Renal Cell Carcinoma in a German Cohort

Renal cell carcinoma (RCC) is among the 10 most common cancer entities and can be categorised into distinct subtypes by differential expression of Krebs cycle genes. We investigated the predictive value of several targeted metabolites with regards to tumour stages and patient survival in an unselect...

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Principais autores: Doreen William, Kati Erdmann, Jonas Ottemöller, Anastasios Mangelis, Catleen Conrad, Mirko Peitzsch, Evelin Schröck, Graeme Eisenhofer, Aristeidis Zacharis, Susanne Füssel, Daniela Aust, Barbara Klink, Susan Richter
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2021-11-01
coleção:Metabolites
Assuntos:
Krebs cycle
metabolic profiling
renal cell carcinoma
subtypes
survival analysis
succinate dehydrogenase mutations
Acesso em linha:https://www.mdpi.com/2218-1989/11/11/764
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