Prothrombinase processivity is conferred by substrate allostery
Abstract The prothrombinase complex, comprised of factor (f) Xa and fVa, converts prothrombin to thrombin through sequential cleavage at two sites in a rapid and processive manner. The molecular basis of prothrombin processing is an enzymatical mystery that to solve requires structural insight into...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Springer Nature
2026-04-01
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| Serie: | The EMBO Journal |
| Accesso online: | https://doi.org/10.1038/s44318-026-00782-4 |
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