TLR-4 ligation of dendritic cells is sufficient to drive pathogenic T cell function in experimental autoimmune encephalomyelitis

<p>Abstract</p> <p>Background</p> <p>Experimental autoimmune encephalomyelitis (EAE) depends on the initial activation of CD4⁺ T cells responsive to myelin autoantigens. The key antigen presenting cell (APC) population that drives the activation of naïve T cells most efficiently is the de...

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Hlavní autoři:	Mellanby Richard J, Cambrook Helen, Turner Darryl G, O’Connor Richard A, Leech Melanie D, Kurschus Florian C, MacDonald Andrew S, Arnold Bernd, Anderton Stephen M
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2012-10-01
Edice:	Journal of Neuroinflammation
Témata:	Multiple sclerosis Experimental autoimmune encephalomyelitis Dendritic cells Myelin basic protein
On-line přístup:	http://www.jneuroinflammation.com/content/9/1/248
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