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Low-intensity focused ultrasound targeted microbubble destruction reduces tumor blood supply and sensitizes anti-PD-L1 immunotherapy

Immune checkpoint blockade (ICB) typified by anti-PD-1/PD-L1 antibodies as a revolutionary treatment for solid malignancies has been limited to a subset of patients due to poor immunogenicity and inadequate T cell infiltration. Unfortunately, no effective strategies combined with ICB therapy are ava...

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Autori principali: Nianhong Wu, Yuting Cao, Ying Liu, Ying Zhou, Hongye He, Rui Tang, Li Wan, Can Wang, Xialin Xiong, Linhong Zhong, Pan Li
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2023-04-01
Serie:Frontiers in Bioengineering and Biotechnology
Soggetti:
immune checkpoint blockade
immune infiltration
antivascular therapy
cavitation
microbubble
low-intensity focused ultrasound
Accesso online:https://www.frontiersin.org/articles/10.3389/fbioe.2023.1173381/full
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