Disturbed shear stress promotes atherosclerosis through TRIM21‐regulated MAPK6 degradation and consequent endothelial inflammation

Abstract Rationale Coronary artery plaques often develop in regions subjected to disturbed shear stress (DSS), yet the mechanisms underlying this phenomenon remain poorly understood. Our study aimed to elucidate the unknown role of MAPK6 in shear stress and plaque formation. Methods In vitro and in...

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Principais autores:	Feng Wang, Shu‐Yu Wang, Yue Gu, Shuai Luo, Ai‐Qun Chen, Chao‐Hua Kong, Wen‐Ying Zhou, Li‐Guo Wang, Zhi‐Mei Wang, Guang‐Feng Zuo, Xiao‐Fei Gao, Jun‐Jie Zhang, Shao‐Liang Chen
Format:	Artigo
Jezik:	Inglês
Izdano:	Wiley 2025-01-01
Serija:	Clinical and Translational Medicine
Teme:	atherosclerosis endothelial inflammation MAPK6 shear stress TRIM21
Online dostop:	https://doi.org/10.1002/ctm2.70168
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