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The HSP-RTK-Akt axis mediates acquired resistance to Ganetespib in HER2-positive breast cancer

Abstract Breast cancer is the leading cause of cancer-related death in women worldwide. Human epidermal growth factor receptor 2 (HER2)-positive subtype comprises 20% of sporadic breast cancers and is an aggressive disease. While targeted therapies have greatly improved its management, primary and a...

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Autori principali: Christopher E. Eyermann, John D. Haley, Evguenia M. Alexandrova
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2021-01-01
Serie:Cell Death and Disease
Accesso online:https://doi.org/10.1038/s41419-021-03414-3
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