ATP-induced asymmetric pre-protein folding as a driver of protein translocation through the Sec machinery

Transport of proteins across membranes is a fundamental process, achieved in every cell by the ‘Sec’ translocon. In prokaryotes, SecYEG associates with the motor ATPase SecA to carry out translocation for pre-protein secretion. Previously, we proposed a Brownian ratchet model for transport, whereby...

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Detalles Bibliográficos

Autores principales:	Robin A Corey, Zainab Ahdash, Anokhi Shah, Euan Pyle, William J Allen, Tomas Fessl, Janet E Lovett, Argyris Politis, Ian Collinson
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	eLife Sciences Publications Ltd 2019-01-01
Colección:	eLife
Materias:	SecA SecYEG protein translocation molecular dynamics hydrogen deuterium exchange (HDX) mass spectrometry electron paramagnetic resonance (EPR) spectroscopy
Acceso en línea:	https://elifesciences.org/articles/41803
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