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Development of a one-tube PAM-independent RCNPM platform using Cas12a for ultra-rapid simultaneous miR-499 and cTnT detection in early acute myocardial infarction diagnosis

Abstract Background Acute myocardial infarction (AMI) benefits from biomarkers and assays that support early triage. Cardiac troponin T (cTnT) is widely used, but may be less informative early after ischemia and can be elevated in non-AMI conditions. Circulating miR-499 has been reported to rise ear...

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Main Authors: Jianguang Guo, Qingsong Wu, Fei Jiang, Meiling Cai, Linfeng Xie, Yuling Xie, Xinfan Lin, Xingfeng Chen, Siying Luo, Xiaofu Dai, Liangwan Chen
Format: Artigo
Language:Inglês
Published: BMC 2026-04-01
Series:Journal of Translational Medicine
Subjects:
Acute myocardial infarction
RCNP
miR-499
cTnT
Cas12a
Translational diagnostics
Online Access:https://doi.org/10.1186/s12967-026-08116-y
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