Long-term Real-world Survival Outcomes with Dual Immune Checkpoint Blockade in Synchronous Metastatic Renal Cell Carcinoma: Implications for the Design of Prospective Cytoreductive Nephrectomy Trials

Background and objective: Patients with synchronous metastatic renal cell carcinoma (s-mRCC) increasingly undergo systemic therapy with their primary tumour in situ. We report long-term survival outcomes and deferred cytoreductive nephrectromy (dCN) rates in an unselected real-world s-mRCC cohort of...

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Hlavní autoři:	Leo Bickley, Elisabeth E. Fransen van de Putte, Luna van den Brink, Laura Marandino, Johannes C. van der Mijn, Sofie Wilgenhof, Johannes V. van Thienen, John B.A.G. Haanen, Ekaterini Boleti, Thomas Powles, Patricia J. Zondervan, Niels M. Graafland, Zayd Tippu, Samra Turajlic, Axel Bex
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2026-01-01
Edice:	European Urology Open Science
Témata:	Renal cell carcinoma Clear-cell metastatic renal cell carcinoma Immune checkpoint inhibitors Ipilimumab Nivolumab Nephrectomy
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2666168325024838
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