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Deciphering interferon functions in avian influenza using receptor knockout models in the natural host

The rapid cross-species transmission of highly pathogenic avian influenza presents a significant zoonotic threat. Elucidating the avian interferon (IFN) system, the primary antiviral defense in chickens, is critical for controlling the virus at its source and preventing its spillover into humans and...

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Principais autores: Mohanned Naif Alhussien, Hanna Kaisa Vikkula, Romina Klinger, Christian Zenner, Simon P Früh, Rashi Negi, Theresa von Heyl, Sabrina Schleibinger, Milena Brunner, Tom VL Berghof, Leora Avolio, Arne Reich, Benjamin Schade, Bassel Aboukhadra, Silke Rautenschlein, Rudolf Preisinger, Hicham Sid, Benjamin Schusser
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications Ltd 2026-06-01
coleção:eLife
Assuntos:
chicken
interferons
genetic modification
CRISPR/Cas9
avian influenza
Acesso em linha:https://elifesciences.org/articles/107855
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