Optogenetic dissection of RET signaling reveals robust activation of ERK and enhanced filopodia-like protrusions of regenerating axons

Abstract RET (REarranged during Transfection) is a receptor tyrosine kinase that transduces various external stimuli into biological functions, such as survival and differentiation, in neurons. In the current study, we developed an optogenetic tool for modulating RET signaling, termed optoRET, combi...

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Hlavní autoři:	Bobae Hyeon, Heeyoung Lee, Nury Kim, Won Do Heo
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2023-07-01
Edice:	Molecular Brain
Témata:	Optogenetics RET GDNF PHR Neuron Signaling
On-line přístup:	https://doi.org/10.1186/s13041-023-01046-6
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