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Druggable genetic targets in endometrial cancer✰,✰✰

Background: FBXW7 is frequently somatically mutated in grade 3 endometrioid endometrial cancers (G3EECs) and serous endometrial cancers (SECs), high-risk cancers associated with poor prognosis. CRISPR-edited cell lines identified the proteomic and phosphoproteomic effects of FBXW7 mutation in 3 high...

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Autori principali: Steven Lehrer, Peter H. Rheinstein
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2022-01-01
Serie:Cancer Treatment and Research Communications
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Accesso online:http://www.sciencedirect.com/science/article/pii/S2468294221001982
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