Targeting BCL9/BCL9L enhances antigen presentation by promoting conventional type 1 dendritic cell (cDC1) activation and tumor infiltration

Abstract Conventional type 1 dendritic cells (cDC1) are the essential antigen-presenting DC subset in antitumor immunity. Suppressing B-cell lymphoma 9 and B-cell lymphoma 9-like (BCL9/BCL9L) inhibits tumor growth and boosts immune responses against cancer. However, whether oncogenic BCL9/BCL9L impa...

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Autors principals:	Fenglian He, Zhongen Wu, Chenglong Liu, Yuanyuan Zhu, Yan Zhou, Enming Tian, Rina Rosin-Arbesfeld, Dehua Yang, Ming-Wei Wang, Di Zhu
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Publishing Group 2024-05-01
Col·lecció:	Signal Transduction and Targeted Therapy
Accés en línia:	https://doi.org/10.1038/s41392-024-01838-9
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