CTLA-4 haploinsufficiency presenting with chronic myeloid leukemia, bullous pemphigoid, and PLA2R-positive membranous nephropathy: a case report

Abstract Background Cytotoxic T-lymphocyte–associated protein 4 (CTLA-4) haploinsufficiency is a primary immune-regulatory disorder characterized by T-cell overactivation and multisystem autoimmunity. Malignancies, particularly lymphomas and gastric cancer, have been reported in approximately 12–13%...

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Detalhes bibliográficos

Principais autores:	Nouraldeen Deeb, Salahaldeen Deeb, Fares Sayed Ahmed, Younis Malik Younis Amro, Abdallah Altell, Aliaa khalili
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-01-01
coleção:	Allergy, Asthma & Clinical Immunology
Assuntos:	Case report CTLA-4 haploinsufficiency Chronic myeloid leukemia (CML) Membranous glomerulonephritis (MGN) Paraneoplastic syndromes
Acesso em linha:	https://doi.org/10.1186/s13223-026-01011-7
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