Charting the transition from in vitro gliogenesis to the in vivo maturation of human glial progenitor cells transplanted into the hypomyelinated mouse brain

Abstract Neither rodent models nor in vitro studies of human cells adequately describe the molecular ontogeny of human glial progenitor cells (hGPCs). Here, we use scRNA-seq together with scATAC-Seq and CUT&TAG assessment of chromatin accessibility to track the in vitro genesis and in vivo different...

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Autors principals:	John N. Mariani, Steven J. Schanz, Benjamin Mansky, Xiaolu Wei, Carter C. Long, Devin Chandler-Militello, Hannah E. Aichelman, Nguyen P. T. Huynh, Steven A. Goldman
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2026-04-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-026-71803-3
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