Impaired glymphatic function in the early stages of disease in a TDP-43 mouse model of amyotrophic lateral sclerosis

Abstract Background Multiple lines of evidence suggest possible impairment of the glymphatic system in amyotrophic lateral sclerosis (ALS). To investigate this, we used in vivo magnetic resonance imaging (MRI) to assess glymphatic function early in the course of disease in a transgenic mouse with do...

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Detalhes bibliográficos

Principais autores:	Akram Zamani, Adam K. Walker, Ben Rollo, Katie L. Ayers, Raysha Farah, Terence J. O’Brien, David K. Wright
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2022-03-01
coleção:	Translational Neurodegeneration
Assuntos:	Magnetic resonance imaging Diffusion-weighted imaging Neurodegeneration Cerebrospinal fluid Telomere
Acesso em linha:	https://doi.org/10.1186/s40035-022-00291-4
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