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LncRNA UCA1 Induces Acquired Resistance to Gefitinib by Epigenetically Silencing CDKN1A Expression in Non-small-Cell Lung Cancer

Lung cancer is the most common cancer globally and is associated with high morbidity and mortality. Gefitinib has been widely used for treating advanced non-small-cell lung cancer (NSCLC). However, acquired resistance usually develops, although we still know little about the mechanism underlying thi...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Tianwei Xu, Shuai Yan, Mengwei Wang, Lihua Jiang, Pei Ma, Binbin Lu, Qinnan Chen, Chenchen Wei, Zhaoxia Wang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020-05-01
Schriftenreihe:Frontiers in Oncology
Schlagworte:
lncRNA
UCA1
CDKN1A
NSCLC
gefitinib
resistance
Online-Zugang:https://www.frontiersin.org/article/10.3389/fonc.2020.00656/full
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