Zebrafish <i>mafbb</i> Mutants Display Osteoclast Over-Activation and Bone Deformity Resembling Osteolysis in MCTO Patients

Multicentric carpotarsal osteolysis (MCTO) is a rare skeletal dysplasia with osteolysis at the carpal and tarsal bones. Heterozygous missense mutations in the transcription factor MAFB are found in patients with MCTO. MAFB is reported to negatively regulate osteoclastogenesis in vitro. However, the...

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Hlavní autoři:	Yujie Han, Weihao Shao, Dan Zhong, Cui Ma, Xiaona Wei, Abrar Ahmed, Tingting Yu, Wei Jing, Lili Jing
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2021-03-01
Edice:	Biomolecules
Témata:	MAFB Multicentric Carpotarsal Osteolysis (MCTO) osteoclasts macrophage and monocytes zebrafish
On-line přístup:	https://www.mdpi.com/2218-273X/11/3/480
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