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4119 Cholecystokinin (CCK) Receptor Antagonist Reverses Nonalcoholic Steatohepatitis (NASH) by Reducing Hepatic Macrophages and Inflammatory Cytokines

OBJECTIVES/GOALS: NASH increases the risk of cirrhosis and liver cancer. High-fat diets increase CCK levels and CCK receptors have been identified on fibroblasts and immune cells. We hypothesized that CCK receptor blockade could prevent NASH by altering the hepatic microenvironment and macrophage ac...

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Principais autores: Martha Gay, Anita Safronenka, Hong Cao, Robin Tucker, Narayan Shivapurkar, Annie Kruger, Jill Smith
פורמט: Artigo
שפה:Inglês
יצא לאור: Cambridge University Press 2020-06-01
סדרה:Journal of Clinical and Translational Science
גישה מקוונת:https://www.cambridge.org/core/product/identifier/S2059866120002939/type/journal_article
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