Identification of Putative Equilibrative Nucleoside Transporter Inhibitors Through Dual-Pharmacophore Virtual Screening and Validation in a Gemcitabine-Based Cell Assay

Pharmacological inhibition of the nucleoside transporter hENT1 is a promising therapeutic target across a range of diseases, including cardiovascular disorders, neurodegenerative conditions, and cancer. However, current inhibitors lack drug-like properties, necessitating the development of new inhib...

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Ngā taipitopito rārangi puna kōrero

Ngā kaituhi matua:	Sedra Kremesh, Azza Ramadan, Sedq Ahmad Moutraji, Shaima Hasan, Radwa E. Mahgoub, Imogen R. Coe, Nour Sammani, Lama Abuamer, Noor Atatreh, Mohammad A. Ghattas
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	MDPI AG 2026-04-01
Rangatū:	Molecules
Ngā marau:	hENT hENT inhibitors gemcitabine cancer cell lines MTT assay virtual screening
Urunga tuihono:	https://www.mdpi.com/1420-3049/31/8/1293
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!