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NAD+ prevents chronic kidney disease by activating renal tubular metabolism

Chronic kidney disease (CKD) is associated with renal metabolic disturbances, including impaired fatty acid oxidation (FAO). Nicotinamide adenine dinucleotide (NAD+) is a small molecule that participates in hundreds of metabolism-related reactions. NAD+ levels are decreased in CKD, and NAD+ suppleme...

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Bibliografische Detailangaben
Hauptverfasser: Bryce A. Jones, Debora L. Gisch, Komuraiah Myakala, Amber Sadiq, Ying-Hua Cheng, Elizaveta Taranenko, Julia Panov, Kyle Korolowicz, Ricardo Melo Ferreira, Xiaoping Yang, Briana A. Santo, Katherine C. Allen, Teruhiko Yoshida, Xiaoxin X. Wang, Avi Z. Rosenberg, Sanjay Jain, Michael T. Eadon, Moshe Levi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical investigation 2025-03-01
Schriftenreihe:JCI Insight
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Online-Zugang:https://doi.org/10.1172/jci.insight.181443
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