Pathway selectivity in Frizzleds is achieved by conserved micro-switches defining pathway-determining, active conformations
Abstract The class Frizzled of G protein-coupled receptors (GPCRs), consisting of ten Frizzled (FZD1-10) paralogs and Smoothened, remains one of the most enigmatic GPCR families. This class mediates signaling predominantly through Disheveled (DVL) or heterotrimeric G proteins. However, the mechanism...
Salvato in:
| Autori principali: | , , , , , , , , |
|---|---|
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Portfolio
2023-07-01
|
| Serie: | Nature Communications |
| Accesso online: | https://doi.org/10.1038/s41467-023-40213-0 |
| Tags: |
Nessun Tag, puoi essere il primo ad aggiungerne!!
|