The CIMP-high phenotype is associated with energy metabolism alterations in colon adenocarcinoma

Abstract Background CpG island methylator phenotype (CIMP) is found in 15–20% of malignant colorectal tumors and is characterized by strong CpG hypermethylation over the genome. The molecular mechanisms of this phenomenon are not still fully understood. The development of CIMP is followed by global...

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Principais autores:	Maria S. Fedorova, George S. Krasnov, Elena N. Lukyanova, Andrew R. Zaretsky, Alexey A. Dmitriev, Nataliya V. Melnikova, Alexey A. Moskalev, Sergey L. Kharitonov, Elena A. Pudova, Zulfiya G. Guvatova, Anastasiya A. Kobelyatskaya, Irina A. Ishina, Elena N. Slavnova, Anastasia V. Lipatova, Maria A. Chernichenko, Dmitry V. Sidorov, Anatoly Y. Popov, Marina V. Kiseleva, Andrey D. Kaprin, Anastasiya V. Snezhkina, Anna V. Kudryavtseva
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2019-04-01
Series:	BMC Medical Genetics
Assuntos:	Colon adenocarcinoma CIMP RNA-Seq TCGA Energy metabolism
Acceso en liña:	http://link.springer.com/article/10.1186/s12881-019-0771-5
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