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Effect of MK-801 and clozapine on the proteome of cultured human oligodendrocytes

Separate lines of evidence have demonstrated the involvement of NMDA receptor and oligodendrocyte dysfunctions in schizophrenia. Here we have carried out shotgun mass spectrometry proteome analysis of oligodendrocytes treated with the NMDA receptor antagonist MK-801 to gain potential insights into t...

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Main Authors: Juliana Silva Cassoli, Keiko eIwata, Johann eSteiner, Paul C. Guest, Christoph W Turck, Juliana Minardi Nascimento, Daniel eMartins-de-Souza
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2016-03-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Clozapine
Pharmacology
Proteomics
Schizophrenia
oligodendrocyte
glial cells
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00052/full
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