Disruption of Active Trans-Sialidase Genes Impairs Egress from Mammalian Host Cells and Generates Highly Attenuated Trypanosoma cruzi Parasites

ABSTRACT Trans-sialidases (TS) are unusual enzymes present on the surface of Trypanosoma cruzi, the causative agent of Chagas disease. Encoded by the largest gene family in the T. cruzi genome, only few members of the TS family have catalytic activity. Active trans-sialidases (aTS) are responsible f...

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Auteurs principaux:	Gabriela de A. Burle-Caldas, Nailma S. A. dos Santos, Júlia T. de Castro, Fernanda L. B. Mugge, Viviane Grazielle-Silva, Antônio Edson R. Oliveira, Milton C. A. Pereira, João Luís Reis-Cunha, Anderson Coqueiro dos Santos, Dawidson Assis Gomes, Daniella C. Bartholomeu, Nilmar S. Moretti, Sergio Schenkman, Ricardo T. Gazzinelli, Santuza M. R. Teixeira
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology 2022-02-01
Collection:	mBio
Sujets:	Trypanosoma cruzi trans-sialidase virulence vaccine CRISPR-Cas9
Accès en ligne:	https://journals.asm.org/doi/10.1128/mbio.03478-21
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