Conditional Immortalization of Human Cardiac Fibroblasts for Pro-Fibrotic and Anti-Fibrotic Drug Screening

Background: The development of anti-fibrotic therapies for heart failure is hindered by the absence of phenotypically stable and scalable human cardiac fibroblast (CFB) models suitable for pre-clinical drug screening. This study aimed to establish and validate a conditionally immo...

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Detalhes bibliográficos

Principais autores:	Sushan Wang, Ruijuan Han, Rui Guo, Cheng Wang, Wenan Kang, Jia Liu, Canling Long
Formato:	Artigo
Idioma:	Inglês
Publicado em:	IMR Press 2026-04-01
coleção:	Frontiers in Bioscience-Landmark
Assuntos:	cell immortalization fibroblasts fibrosis myofibroblasts cell transdifferentiation drug evaluation
Acesso em linha:	https://www.imrpress.com/journal/FBL/31/5/10.31083/FBL49465
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