Lactylation of SLC26A3 in the acidic tumor microenvironment promotes malignant progression of colorectal carcinoma

Abstract The acidic tumor microenvironment provides the energy that drives the development of malignant tumors. High concentrations of lactic acid and H+ are key features of the acidic tumor microenvironment, and lactylation has gradually been shown to play a significant role in tumor progression. T...

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Autori principali:	Chong Chen, Du Cai, Xuanhui Liu, Yifan Zheng, Xinxin Huang, Dongwen Chen, Jiawei Cai, Yiran Bie, Zhengran Zhou, Chuling Hu, Zhengyu Wei, Kuntai Cai, Ting Li, Shuzhen Luo, Dongbing Liu, Kui Wu, Zerong Cai, Feng Gao, Xiaojian Wu, Peishan Hu
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 2026-01-01
Serie:	Cell Death and Disease
Accesso online:	https://doi.org/10.1038/s41419-026-08422-9
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