Insights into the production and evolution of lantibiotics from a computational analysis of peptides associated with the lanthipeptide cyclase domain

Lanthipeptides are a large group of ribosomally encoded peptides cyclized by thioether and methylene bridges, which include the lantibiotics, lanthipeptides with antimicrobial activity. There are over 100 experimentally characterized lanthipeptides, with at least 25 distinct cyclization bridging pat...

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Bibliografische Detailangaben

Hauptverfasser:	Nikunj Maheshwari, Lars S. Jermiin, Chiara Cotroneo, Stephen V. Gordon, Denis C. Shields
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	The Royal Society 2024-07-01
Schriftenreihe:	Royal Society Open Science
Schlagworte:	antibiotic lanthipeptide lantibiotic evolution cyclic peptide bridging
Online-Zugang:	https://royalsocietypublishing.org/doi/10.1098/rsos.240491
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