Efficacious human metapneumovirus vaccine based on AI-guided engineering of a closed prefusion trimer

Abstract The prefusion conformation of human metapneumovirus fusion protein (hMPV Pre-F) is critical for eliciting the most potent neutralizing antibodies and is the preferred immunogen for an efficacious vaccine against hMPV respiratory infections. Here we show that an additional cleavage event in...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Mark J. G. Bakkers, Tina Ritschel, Machteld Tiemessen, Jacobus Dijkman, Angelo A. Zuffianò, Xiaodi Yu, Daan van Overveld, Lam Le, Richard Voorzaat, Marlies M. van Haaren, Martijn de Man, Sem Tamara, Leslie van der Fits, Roland Zahn, Jarek Juraszek, Johannes P. M. Langedijk
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Nature Portfolio 2024-07-01
Sarja:	Nature Communications
Linkit:	https://doi.org/10.1038/s41467-024-50659-5
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