Machine-learning–guided transcriptomic integration identifies GFM1 as a lactylation-related candidate biomarker in aortic dissection

Abstract Aortic dissection (AD) is a life-threatening aortic disease with limited disease-modifying pharmacologic options. Lysine lactylation is a metabolism-linked post-translational modification implicated in vascular and inflammatory biology, but its relationship to AD has not been well character...

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Autori principali:	Junquan Chen, Nan Jiang, Zhigang Guo, Yunpeng Bai
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2026-02-01
Serie:	Scientific Reports
Soggetti:	Aortic dissection Lactylation Integrative transcriptomics Machine learning GFM1 Vascular smooth muscle cells
Accesso online:	https://doi.org/10.1038/s41598-026-40139-9
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