The amino acid substitutions A30W, K28A, and M35C alter amyloid-β peptide toxicity in cell culture and in an in vivo model of amyloidosis in Caenorhabditis elegans
The buildup of toxic aggregates formed by the amyloid-β peptide 1–42 (Aβ42) is a central process in Alzheimer’s disease (AD) pathology. The peptide’s self-assembly and toxicity are highly dependent on its primary amino acid sequence and can be altered by modifying key residues. Specifically, the sin...
Sábháilte in:
| Príomhchruthaitheoirí: | , , , , , , , , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe / Cruthaithe: |
Frontiers Media S.A.
2026-06-01
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| Sraith: | Frontiers in Aging Neuroscience |
| Ábhair: | |
| Rochtain ar líne: | https://www.frontiersin.org/articles/10.3389/fnagi.2026.1843210/full |
| Clibeanna: |
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