Heteroaryl derivatives of suvorexant as OX1R selective PET ligand candidates: Cu-mediated 18F-fluorination of boroxines, in vitro and initial in vivo evaluation

Abstract Background The orexin receptor (OXR) plays a role in drug addiction and is aberrantly expressed in colorectal tumors. Subtype-selective OXR PET ligands suitable for in vivo use have not yet been reported. This work reports the development of 18F-labeled OXR PET ligand candidates derived fro...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Kim-Viktoria Bolik, Jan Hellmann, Simone Maschauer, Eduard Neu, Jürgen Einsiedel, Patrick Riss, Nora Vogg, Jörg König, Martin F. Fromm, Harald Hübner, Peter Gmeiner, Olaf Prante
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	SpringerOpen 2024-09-01
Sarja:	EJNMMI Research
Aiheet:	Orexin receptor Suvorexant F-18 Cu-mediated 18F-fluorination PET
Linkit:	https://doi.org/10.1186/s13550-024-01141-2
Tagit:	Lisää tagi Ei tageja, Lisää ensimmäinen tagi!