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The Unifying Hypothesis of Alzheimer’s Disease: Heparan Sulfate Proteoglycans/Glycosaminoglycans Are Key as First Hypothesized Over 30 Years Ago

The updated “Unifying Hypothesis of Alzheimer’s disease” (AD) is described that links all the observed neuropathology in AD brain (i.e., plaques, tangles, and cerebrovascular amyloid deposits), as well as inflammation, genetic factors (involving ApoE), “AD-in-a-Dish” studies, beta-amyloid protein (A...

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Bibliografiske detaljer
Principais autores: Alan David Snow, Joel A. Cummings, Thomas Lake
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021-10-01
Serier:Frontiers in Aging Neuroscience
Fag:
Online adgang:https://www.frontiersin.org/articles/10.3389/fnagi.2021.710683/full
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