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Predominant Role of Immunoglobulin G in the Pathogenesis of Splenomegaly in Murine Lupus

Systemic lupus erythematosus (SLE) is characterized by high levels of autoantibodies and multiorgan tissue damage. The pathogenesis of splenomegaly in SLE remains unknown. In this study, the role of immunoglobulin G (IgG) generation and deposition in the inflammation of the spleen and associated dys...

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Principais autores: Qian Zhang, Liping Xiang, Muhammad Haidar Zaman, Wenhui Dong, Guodan He, Guo-Min Deng
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-01-01
coleção:Frontiers in Immunology
Assuntos:
immunoglobulin G
systemic lupus erythematosus
spleen
inflammation
macrophages
germinal center
Acesso em linha:https://www.frontiersin.org/article/10.3389/fimmu.2019.03020/full
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