Regulation of human T-lymphotropic virus type I latency and reactivation by HBZ and Rex.

Human T lymphotropic virus type I (HTLV-I) infection is largely latent in infected persons. How HTLV-1 establishes latency and reactivates is unclear. Here we show that most HTLV-1-infected HeLa cells become senescent. By contrast, when NF-κB activity is blocked, senescence is averted, and infected...

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Hlavní autoři:	Subha Philip, Muhammad Atif Zahoor, Huijun Zhi, Yik-Khuan Ho, Chou-Zen Giam
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Public Library of Science (PLoS) 2014-04-01
Edice:	PLoS Pathogens
On-line přístup:	https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004040&type=printable
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