Hyper-fractionated radiotherapy as a bridging strategy to enhance CAR-T efficacy by regulating T-cell co-stimulatory molecules in relapsed/refractory diffuse large B-cell lymphoma

BackgroundBridging therapy can prevent patients from disease progression while waiting for CAR-T cell preparation. Hyper-fractionated radiotherapy can achieve an effective target dose within a short period, minimize radiation damage, and may modify immune environment compared to conventional radioth...

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Hlavní autoři:	Jing Ruan, Daobin Zhou, Yan Zhang, Danqing Zhao, Chong Wei, Ke Hu, Fuquan Zhang, Xiaorong Hou, Wei Zhang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2024-12-01
Edice:	Frontiers in Immunology
Témata:	hyper-fractionated radiotherapy DLBCL CAR-T bridging therapy T-cell co-stimulatory molecules
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1481080/full
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