T-cell exhaustion in tumor immunology: mechanisms, heterogeneity, and therapeutic strategies
T-cell exhaustion is a central mechanism limiting the durability of antitumor immunity and the long-term efficacy of cancer immunotherapy. Arising under persistent antigenic stimulation and sustained microenvironmental stress, exhausted CD8+ T cells undergo progressive functional impairment accompan...
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| Principais autores: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Frontiers Media S.A.
2026-05-01
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| Serier: | Frontiers in Immunology |
| Fag: | |
| Online adgang: | https://www.frontiersin.org/articles/10.3389/fimmu.2026.1841281/full |
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