Pharmacophore-based virtual screening and in silico investigations of small molecule library for discovery of human hepatic ketohexokinase inhibitors for the treatment of fructose metabolic disorders

IntroductionExcessive fructose consumption is a significant driver of metabolic disorders, including obesity, diabetes, non-alcoholic fatty liver disease and non-alcoholic steatohepatitis primarily by promoting insulin resistance and fat accumulation. Ketohexokinase C (KHK-C), a pivotal enzyme in fr...

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Автори:	Tilal Elsaman, Magdi Awadalla Mohamed, Abozer Y. Elderdery, Abdullah Alsrhani, Badr Alzahrani, Heba Bassiony Ghanem, Jeremy Mills, Musaed Rayzah, Nasser A. N. Alzerwi, Afnan Al-sultan, Bandar Idrees, Fares Rayzah
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Frontiers Media S.A. 2025-04-01
Серія:	Frontiers in Pharmacology
Предмети:	fructose diabetes obesity dyslipidemia ketohexokinase
Онлайн доступ:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1531512/full
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