Cytoskeletal perturbation leads to platelet dysfunction and thrombocytopenia in variant forms of Glanzmann thrombasthenia

Several patients have been reported to have variant dominant forms of Glanzmann thrombasthenia, associated with macrothrombocytopenia and caused by gain-of-function mutations of ITGB3 or ITGA2B leading to reduced surface expression and constitutive activation of integrin αIIbβ3. The mechanisms leadi...

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Xehetasun bibliografikoak

Egile Nagusiak:	Loredana Bury, Emanuela Falcinelli, Davide Chiasserini, Timothy A. Springer, Joseph E. Italiano, Paolo Gresele
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Ferrata Storti Foundation 2016-01-01
Saila:	Haematologica
Sarrera elektronikoa:	https://haematologica.org/article/view/7605
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