Engineered exosome-loaded decellularized biomimetic periosteum regulates M2 macrophage polarization via PI3K/AKT/mTOR-activated autophagy to enhance angiogenic osteogenesis

Critical-sized bone defects remain a clinical challenge due to dysregulated inflammation that impairs angiogenesis. Here, we developed a cell-free biomaterial system consisting of a decellularized biomimetic periosteum (DBP) loaded with engineered exosomes derived from nanoporous titanium–preconditi...

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Главные авторы:	Jiali Deng, Xiaoqiong Huang, Yang Yang, Linjuan Li, Jiaqi Shen, Wenyi Zeng, Xiaolin Yu, Feilong Deng, Ruogu Xu, Zhengchuan Zhang
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Elsevier 2026-06-01
Серии:	Materials & Design
Предметы:	Engineered exosomes Nanoporous titanium Macrophage Autophagy Biomimetic periosteum Critical-sized bone defects
Online-ссылка:	http://www.sciencedirect.com/science/article/pii/S0264127526008208
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