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Sprouty4 at the crossroads of Trk neurotrophin receptor signaling suppression by glucocorticoids

Glucocorticoids (GC) affect neuronal plasticity, development and function of the nervous system by inhibiting neurotrophin-induced Trk signaling. It has been established that pretreatment with dexamethasone (DEX) restricts Neurotrophin-induced neurite outgrowth by inhibiting Trk-dependent activation...

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Principais autores: Facundo Ferrero Restelli, Fernando Federicci, Fernanda Ledda, Gustavo Paratcha
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2023-02-01
coleção:Frontiers in Molecular Neuroscience
Assuntos:
neurotrophins
Trk receptors
glucocorticoids
Sprouty4
Erk/MAPK pathway
neuronal differentiation
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1090824/full
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