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Synthesis of Novel <i>ent</i>-Kaurane-Type Diterpenoid Derivatives Effective for Highly Aggressive Tumor Cells

We have designed and synthesized 6 <i>ent</i>-Kaurane-type diterpenoid derivatives containing &#945;,&#946;-unsaturated ketone moieties. In vitro, activity was evaluated against three human tumor cell lines and a rat myogenic cell line (HepG2, NSCLC-H292, SNU-1040, L6) by MTT assay. All the tested c...

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Bibliografiske detaljer
Principais autores: Yu Hu, Xiao-Nian Li, Ze-Jin Ma, Pema-Tenzin Puno, Yong Zhao, Yan Zhao, Ye-Zhi Xiao, Wei Zhang, Jing-Ping Liu
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2018-12-01
Serier:Molecules
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Online adgang:https://www.mdpi.com/1420-3049/23/12/3216
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