Intrahost viral evolution of SARS-CoV-2 infections in rheumatic versus hematological patients with severe iatrogenic immunosuppression

ObjectivesImmunocompromised patients with B-cell depletion are at risk of ongoing SARS-CoV-2 replication that can lead to intra-host genomic divergence, immune escape during treatment and potentially emergence of novel variants.MethodsWe conducted a prospective observational study including severely...

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Auteurs principaux:	Emmanouil Karofylakis, Theodoros Loupis, Andromachi Blizou, Eleni Ntalaouti, Eirini Maria Stergioti, Giannis Vatsellas, Sotirios Tsiodras, Anastasia Antoniadou, Aggelos Banos, Konstantinos Thomas
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2026-04-01
Collection:	Frontiers in Medicine
Sujets:	immunosuppression intrahost evolution rituximab SARS-CoV-2 virome sequencing
Accès en ligne:	https://www.frontiersin.org/articles/10.3389/fmed.2026.1715096/full
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